Cargador de baterías inductivo para dispositivos alimentados por USB

El objeto del proyecto enunciado consiste en la redacción y diseño de un prototipo de cargador de baterías inductivo para dispositivos que utilicen el sistema de alimentación USB. Este desarrollo servirá como base a futuras investigaciones o mejoras que permitan incorporar con comodidad y total seguridad esta tecnología de recarga inalámbrica al dispositivo que se dese

Generador de eventos visuales y sonoros

El proyecto de “Generador de eventos visuales y sonoros” responde a la propuesta realizada por grupo de investigación Tecnodiscap realizada al comienzo del curso 2010- 2011. En dicho proyecto se pidió como requerimiento una señal luminosa de una potencia que iría entre 1W y 3W, una señal acústica y todo ello controlado con comunicación inalámbrica. Como señal luminosa se eligió un diodo led RGB de una potencia de 3W tras buscar la mejor opción que ofrecía el mercado teniendo en cuenta la relación prestacionesprecio. Para suministrar la corriente necesaria al diodo led en cada caso se tuvieron que buscar los drivers correspondientes que necesitaran el mínimo número de componentes adicionales y si fuera posible evitando componentes inductivos como bobinas. Como señal acústica se tienen dos opciones, un buzzer, el cual se ha programado para tener la posibilidad de reproducir cualquiera de las notas en cualquiera de las octavas musicales y en el que además como concatenación se pueden reproducir melodías, y además también se ofrece la posibilidad de conectar el altavoz como medida de mejora respecto a la calidad de audio. Las conexiones necesarias para el altavoz estaban ya validadas por el grupo Tecnodiscap. La comunicación inalámbrica se hace mediante módulos ZigBee, los cuales son muy útiles para este tipo de usos en los que no se tiene que estar transmitiendo información todo el rato sino solamente en casos puntuales. Se han diseñado tres pcbs, una que alberga los dispositivos de aviso y dos variantes de pcb con el control y fuente de alimentación. Además se ha buscado la caja en la que irían colocadas, dejándolas así listas para su fabricación. La programación se ha llevado a cabo con un kit de desarrollo facilitado por el grupo Tecnodiscap, que además de lo estrictamente necesario, disponía de un LCD y de pulsadores y diodos led que sirvieron para lograr el aprendizaje del uso del kit y de la posterior implementación del código de programación de una manera más fácil. Una vez programado todo, se realizó la migración a otro kit de desarrollo, el cual contenía el modelo del micro que figura en la placa de control diseñada ya que dispone de los pines suficientes con PWM que nos permite controlar nuestros dispositivos. Además dispone de los componentes de audio necesarios para el uso del altavoz, al contar con un amplificador de audio y de todos los demás componentes necesarios

Thermal processing of raspberry pulp: Effect on the color and bioactive compounds

The effect of heating on color degradation and the bioactive compounds, such as total monomeric anthocyanins (TMA), L-ascorbic acid (AA) and total polyphenols (TP), of raspberry pulp were investigated at 70, 80, 90 and 100 °C for 2 h. The changes in a* (redness-greenness), chroma (C*) and browning index (BI) color parameters followed a first-order reaction with activation energies of 39.39, 35.60 and 51.17 kJ mol−1, respectively. The degradation of TMA and AA also followed first order kinetics while TP did not show significant variations with thermal treatment. The activation energies of the TMA and AA changes were 28.36 and 29.47 kJ mol−1, respectively. In addition, the activation energies revealed that BI was the most sensitive parameter towards temperature changes, while the reaction rate constants (k) showed that AA had the highest degradation rate in comparison with the other parameters studied. The degradation of TMA showed a strong positive correlation with a*. The results obtained in this study may be useful to food processors for designing and optimizing thermal treatment conditions in order to obtain high quality raspberry pulp products.Fil: Badin, Emiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Montenegro, Mariana Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Ibarz, A.. Universidad de Lleida; EspañaFil: Ribotta, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Lespinard, Alejandro Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentin

Study of the therapeutic effects of an advanced hippotherapy simulator in children with cerebral palsy: a randomised controlled trial

<p>Abstract</p> <p>Background</p> <p>Although hippotherapy treatment has been demonstrated to have therapeutic effects on children with cerebral palsy, the samples used in research studies have been very small. In the case of hippotherapy simulators, there are no studies that either recommend or advise against their use in the treatment of children with cerebral palsy. The aim of this randomised clinical study is to analyse the therapeutic effects or the contraindications of the use of a commercial hippotherapy simulator on several important factors relating to children with cerebral palsy such as their motor development, balance control in the sitting posture, hip abduction range of motion and electromyographic activity of adductor musculature.</p> <p>Methods/Design</p> <p>The study is a randomised controlled trial. It will be carried out with a sample of 37 children with cerebral palsy divided into two treatment groups. Eligible participants will be randomly allocated to receive either (a) Treatment Group with hippotherapy simulator, maintaining sitting posture, with legs in abduction and rhythmic movement of the simulator or (b) Treatment Group maintaining sitting posture, with legs in abduction and without rhythmic movement of the simulator. Data collection and analysis: all measurements will be carried out by a specially trained blind assessor. To ensure standardization quality of the assessors, an inter-examiner agreement will be worked out at the start of the study. The trial is funded by the Department of Research, Innovation and Development of the Regional Government of Aragon (Official Bulletin of Aragon 23 July 2007), project number PM059/2007.</p> <p>Discussion</p> <p>Interest in this project is due to the following factors: Clinical originality (there are no previous studies analysing the effect of simulators on the population group of children with CP, nor any studies using as many variables as this project); Clinical impact (infantile cerebral palsy is a chronic multisystemic condition that affects not only the patient but also the patient's family and their close circle of friends); Practical benefits (the development of an effective treatment is very important for introducing this element into the rehabilitation of these children).</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN03663478.</p

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Identità sessuata e teoria di Gender

Uno dei temi oggi più dibattuti è il tema dell’identità sessuale riferito alla persona umana. Infatti da quando la cosiddetta “teoria di genere” è uscita dai contesti accademici proponendosi alla scena giuridica internazionale, intere società nazionali sono state coinvolte in un lavoro di ristrutturazione secondo schemi antropologici inediti. Scopo del presente lavoro è quello di approfondire l’argomento, partendo proprio dalla terminologia, dal senso compiuto dalle parole utilizzate allo scopo di favorire una maggior comprensione su un dibattito così delicato e cocente qual è la volontà di una radicale rielaborazione dell’umano così come ci è stato consegnato dalla Storia

Kinetic modeling of thermal degradation of color, Lycopene, and ascorbic acid in crushed tomato

The kinetics of the thermal degradation of color (L*, a*, and b* coordinates), lycopene (L), and L-ascorbic acid (AA) in crushed tomato were studied over a temperature range of 70 to 100 °C. These results showed that the changes in a*, L, and AA followed a first-order kinetic model (R2 > 0.91), while those for L* and b* did not fit any suitable kinetic models. The temperature effects on degradation rates were adequately compatible with the Arrhenius equation (R2 > 0.96) with the following activation energy values (Ea, kJ mol−1): a* (64.54), L (45.96) and AA (25.69). These Ea values indicated that a* was the most sensitive parameter towards temperature changes, while the reaction rate constants (k) showed that L had the highest degradation rate compared with the other parameters studied. A linear relationship between a* and L content was found, suggesting that a* measured instantaneously by tristimulus colorimeters can be used for the online determination of L degradation in crushed tomatoes during heat treatment. The knowledge gained from this study could be useful for improving the design and optimization of the thermal process of crushed tomato in order to preserve its nutritional value and sensory quality.Fil: Badin, Emiliano Emanuel. Universidad Nacional de Villa María; ArgentinaFil: Quevedo Leon, R.. Universidad de Los Lagos; ChileFil: Ibarz, A.. Universidad de Lleida; EspañaFil: Ribotta, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Lespinard, Alejandro Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentin

Histone Deacetylase 11 (HDAC11) Plays as a Novel Transcriptional Regulator in Hematopoiesis under Pathological Conditions

During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual hematopoietic lineages. In normal myelopoiesis, the immature myeloid cells (IMCs) differentiate into macrophages, neutrophils or dendritic cells. However, under tumor burden, these IMCs differentiate into myeloid derived suppressor cells (MDSCs) result in an upregulation of immune suppressive factors1. The development of normal or malignant is tightly controlled by endogenous signals such as transcription factors and epigenetic regulations. HDAC11 is the newest identified members of the histone deacetylase (HDAC) family. Previous study in our group had identified HDAC11 as a negative regulator of interleukin 10 (IL-10) production in antigen-presenting cells(APCs). However, the mechanisms of HDAC11 in normal and malignant hematopoiesis remains unclear. We have uncovered for the first time that in the absence of HDAC11, upon LPS stimulation, neutrophils isolated form mice displays an overproduction of pro-inflammatory cytokines such as TNF-alpha and IL-6 using both mRNA and protein analysis. Strikingly, these HDAC11 KO neutrophils showed a significantly higher migratory and phagocytosis activity, resulting from an overexpression of the migratory receptor and cytokine CXCR/L2. We have performed Chromatin Immunoprecipitation (ChIP) analysis on the neutrophils and discovered that HDAC11 was recruited to the promoter regulatory region of these genes we have identified. Not only does HDAC11 plays a crucial role in the neutrophil function, our group have also found out that lacking of HDAC11 increase the suppressive activity of Myeloid-drived Suppressor Cells (MDSCs). The previous publication of our group had shown that the tumor bearing mice experienced a much more aggressive growth pattern in the HDAC11 KO mice compare with C57BL/6 wild type control. We observed a markedly higher expression of the lineage-specific transcription factor C/EBP-β mRNA in the CD11b+/Ly6G+ granulocytic compartment the CD11b+/Ly6C+ monocytic compartments of HDAC11KO mice relative to control mice. C/EBP-β has been proved to play a crucial role in the MDSCs generation and function2. To explore the mechanism we found out that HDAC11 was recruited to the promoter region of C/EBP-β of the primary myeloid cells. Taken together, we have uncovered a previously unknown role for HDAC11 as a transcriptional regulator in neutrophils and MDSCs function. In the absence of HDAC11, neutrophils function more pro-inflammatory upon infection. And interestingly, HDAC11 may function as an epigenetic checkpoint of C/EBP-β gene expression in the MDSCs under tumor condition. Our findings will lead to a better understanding of this novel role of HDAC11 in myeloid biology under different pathological conditions

Mejoramiento de bioaceites obtenidos del procesamiento hidrotermal solar de biomasa

Póster presentado en la 9ª Jornada de Jóvenes Investigadores de Química y Física de Aragón, celebrada el 16 de diciembre de 2021 en Zaragoza.El procesamiento hidrotermal es una tecnología prometedora por llevarse a cabo a temperaturas más bajas que la pirólisis o la gasificación y presentar la capacidad de procesar biomasa con un alto contenido de humedad (hasta 70%), lo que ahorra el proceso de secado. Sin embargo, el procesamiento hidrotermal emplea generalmente energía generada por combustibles fósiles para la generación de calor. Dicho impacto medioambiental podría evitarse mediante el uso de energía solar concentrada como fuente de calor. El procesamiento hidrotermal solar a 250°C permite producir aceites con mayor poder calorífico que los obtenidos mediante pirólisis a 450°C. El mejoramiento del bioaceite por hidrodesoxigenación catalítica utilizando carburo de molibdeno soportado en nanofibras de carbono permite incrementar su poder calorífico hasta un 34%.Este trabajo se ha realizado en el marco del proyecto de I+D+i PID2020-115053RB-I00, financiado por MCIN/ AEI/10.13039/501100011033.Peer reviewe

Biomass-derived nanocarbon materials for biological applications: challenges and prospects

4 figures, 1 table.Biomass-derived nanocarbons (BNCs) have attracted significant research interests due to their promising economic and environmental benefits. Following their extensive uses in physical and chemical research domains, BNCs are now growing in biological applications. However, their practical biological applications are still in their infancy, requiring critical evaluations and strategic directions, which are provided in this review. The carbonization of biomass sources and major types of BNCs are introduced, encompassing carbon nanodots, nanofibres, nanotubes, and graphenes. Next, essential biological uses of BNCs, antibacterial/antibiofilm materials (nanofibres and nanodots) and bioimaging agents (predominantly nanodots), are summarized. Furthermore, the future potential of BNCs, for designing wound dressing/healing materials, water and air disinfection platforms, and microbial electrochemical systems, is discussed. We reach the conclusion that a crucial challenge is the structural control of BNCs. Furthermore, a key knowledge gap for realizing practical biological applications is the lack of systematic comparisons of BNCs with nanocarbons of synthetic origin in the current literature. Although we did not attempt to perform an exhaustive literature survey, the evaluation of the existing results indicates that BNCs are promising as easily accessible materials for various biomedically and environmentally relevant applications.Y. C. acknowledges financial support from the Australian Research Council under the Future Fellowships scheme (FT160100107) and a Tianjin city-sponsored short-term visiting project.Peer reviewe